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pentobarbital will lower the extent or influence of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.pentobarbital will decrease the extent or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with robust CYP3A4 inducers is not advi